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Is the Efficacy of Herbavate is Proven?

The efficacy and tolerability of HERBAVATE cream is well supporThe efficacy and tolerability of HERBAVATE cream is well supported by comparative clinical studies. During clinical studies on patients suffering from eczema, the cream has been found to produce effect similar to topical steroids with respect to controlling the severity of clinical symptoms of pruritus (itching), scaling, thickening and redness associated with eczema. On global assessment HERBAVATE was rated more favorably by both patients and physicians.


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Preclinical Studies:

On Preclinical studies, the formulation showed good activity (85% reduction in infected area) on infected dogs skin after repeated topical applications for 15 days.

Clinical Studies:

Three studies of varying duration have been carried out with HERBAVATE cream at various Medical Colleges in India. The first study was a pilot non-comparative study of one month duration. In the second and third study HERBAVATE cream was compared with betamethasone a potent steroid.

Clinical Study 1:

Herbavate in Eczema Patients suffering from eczema applied HERBAVATE cream over the lesion twice daily and were followed up weekly for 4 weeks. At the end of the study there was significant improvement in all symptoms of eczema including erythema, scaling, lichenification and pruritis. HERBAVATE was well tolerated by most of the patients.

Mean change in weekly score for symptoms of eczema over 4 weeks

Clinical Study 2:

HERBAVATE cream vs. topical Betamethasone in Eczema Patients suffering from eczema applied either HERBAVATE cream or topical Betamethasone over the lesion twice daily and were followed up weekly for 4 weeks. HERBAVATE was assessed as having a better efficacy and local tolerance by a larger number of patients.

Clinical Study 3:

HERBAVATE cream vs. topical Betamethasone + Antibiotic in Eczema Patients suffering from eczema applied either HERBAVATE cream or topical Betamethasone+ antibiotic over the lesion twice daily and were followed up to 3 months. The study concluded that both HERBAVATE and steroids compare well in terms of reduction in severity of symptoms. The global rating for HERBAVATE is better as compared to steroids.

This is probably due to the better tolerance of HERBAVATE. Steroids are known to be associated with side effects especially on the long term.

Results:


Before		After 4 weeks of Application

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Conclusion:

Clinical studies with HERBAVATE cream have shown it to be as effective as topical steroids in the management of symptoms of eczema like itching, redness, thickening and scaling. Unlike steroid it can be used for longer durations. Clinical studies have shown the efficacy and safety of HERBAVATE cream for up to 3 months of application. More studies are underway.

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